![]() ![]() This suggests that prehospital i-STAT POC cTn could be useful to rule-in MI, but should not be used to exclude MI.Ĭhest pain myocardial infarction point-of-care prehospital troponin. Conclusions: Prehospital POC i-STAT cTn measurement in patients transported with acute chest pain was highly specific for MI but had low sensitivity. Compared to POC cTn, the central lab cTn measurement of prehospital blood resulted in a higher sensitivity of 67.9% (95% CI 53.7-80.1%, p < 0.0001), but lower specificity of 92.4% (95% CI 88.4-95.4%, p = 0.0001). The specificity and positive predictive value of the POC cTn measurement were 99.2% (95% CI 97.5-99.8%) and 85.7% (95% CI 63.7-97.0%) for MI. MI was adjudicated in 16.2% (68/421) during the index visit. Results: During the study period prehospital POC cTn results were obtained on 421 patients, of which 5.0% (21/421) had results >99th percentile upper reference limit. Test characteristics (sensitivity, specificity, and predictive values) for detection of MI were calculated for POC and central lab cTn measurement of prehospital blood and compared with McNemar's test. Index visit MI was adjudicated by 3 experts using central lab cTn measures from the patient's clinical blood draws. ![]() Blood collected during ambulance transport was also analyzed for cTn in the central lab. Following ED arrival, participants received standard evaluations including clinical blood draws for cTn measurement in the hospital central lab (AccuTnI +3 assay Beckman Coulter, or cTnI-Ultra assay Siemens). During ambulance transport paramedics initiated intravenous access, collected blood, and used a POC device (i-STAT Abbott Laboratories) to measure cTn. Patients with ST-elevation MI on ECG were excluded. Methods: A prospective cohort study of adults with non-traumatic chest pain was conducted in three Emergency Medical Services agencies (December 2016 to January 2018). The objective of this study was to prospectively test the performance of POC cTn measurement by paramedics to detect myocardial infarction (MI) among patients transported to the ED for acute chest pain. The i-Stat System performs point of care blood analysis using a single disposable cartridge which contains microfabricated sensors, a calibrant solution, fluidics system, and a waste chamber. However, data examining POC cTn measurement in the prehospital setting, during ambulance transport, are limited. For i-STAT test cartridge information and intended use, refer to individual product pages or the cartridge information (CTI/IFU) in the i-STAT Support area.Ībbott - A Leader in Rapid Point-of-Care Diagnostics.Objective: Use of point-of-care (POC) troponin (cTn) testing in the Emergency Department (ED) is well established. Check with your local representative for availability in specific markets. Not all products are available in all regions. GDPR Statement | Declaration for California Compliance Law. Any person depicted in such photographs is a model. Photos displayed are for illustrative purposes only. ![]() Your use of this website and the information contained herein is subject to our Website Terms and Conditions and Privacy Policy. The products and information contained herewith may not be accessible in all countries, and Abbott takes no responsibility for such information which may not comply with local country legal process, regulation, registration and usage. This website is governed by applicable U.S. A troponin level above 0.4 ng/ml suggests a probable heart attack. No use of any Abbott trademark, trade name, or trade dress in this site may be made without the prior written authorization of Abbott, except to identify the product or services of the company. A troponin level between 0.04 ng/ml and 0.39 ng/ml often indicates a problem with the heart. Unless otherwise specified, all product and service names appearing in this Internet site are trademarks owned by or licensed to Abbott, its subsidiaries or affiliates. ![]()
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